Dr Dennis Gross has just dropped what might be its biggest launch of the year – the DRx BioRejuvenation Serum, and honestly, the claims alone are enough to make you stop scrolling.
Billed as “the future of facial rejuvenation,” this one is going after visibly tighter, lifted, sculpted skin, which is a big step up from the brightening and resurfacing territory the brand usually plays in. So here are my first thoughts before it lands on my skin.
What’s actually in it
The headline act is a combination the brand is calling Collagen Amino Acids + G.N.A. Translated out of skincare marketing speak:
- Collagen amino acids – the individual building blocks that make up collagen (think glycine, proline, alanine and friends), rather than collagen itself, which is too large a molecule to do much once you’ve slathered it on.
- G.N.A. – Glutathione, Niacinamide and Adenosine, which the brand says work as precursors to NAD+, essentially trying to fire up the skin’s energy cycle rather than just sit on the surface.
On paper, that’s a genuinely different angle to most “firming” serums, which tend to lean on peptides alone. This one is trying to hit both the structural side (amino acids feeding collagen production) and the cellular energy side (via NAD+ precursors) at once. Whether that translates to real-world results is the bit I’m always sceptical about until I’ve used something for a good few weeks myself.
Where it’s meant to work
Dr Dennis Gross is specifically calling out the nasolabial folds, jawline, jowls and neck, so this isn’t a general “anti-ageing serum,” it’s positioned as a targeted lifting and firming treatment for the lower face. That’s a smart, specific claim to make rather than the usual vague “reduces the appearance of fine lines” line every serum uses.
The numbers they’re leading with
The brand has published some punchy clinical stats:
- 84% saw visibly firmer, tighter, more resilient skin after 8 weeks
- 90% said skin felt firmer, tighter and revitalised after 12 weeks
- 96% said their skin looked rejuvenated after 12 weeks
Both studies were run on 50 participants, which is worth flagging – solid for an in-house clinical, but I’d always want to see how that holds up against a proper independent review before taking the percentages as gospel.
How you’re meant to use it
Simple enough: once a day, AM or PM, 2–3 pumps massaged into clean, dry skin. It slots into the usual DDG routine order – cleanse, LED, peel, serums thinnest to thickest, eye cream, moisturiser, SPF in the morning. No complicated layering rules, which I always appreciate.
Price and where it sits
It’s launched at $89 for 30ml, which puts it comfortably in the same bracket as the brand’s other serious treatment serums, not the premium end of the DDG range. For a formula with this many active ingredients on the list, that’s not an unreasonable ask.
My first impression
I like that this isn’t just another vitamin C or retinol reshuffle – the NAD+ energy angle feels like it’s chasing where the science conversation in skincare is actually heading right now, rather than repackaging an old idea with a new name. The targeted claims (jawline, jowls, neck) are also refreshingly specific for a launch like this.
That said, “future of facial rejuvenation” is a big line to live up to, and in-house clinical stats always deserve a healthy dose of scepticism until real skin has real time with it. I’ll be testing this properly over the coming weeks and will report back with an honest verdict – good, bad, and anything in between.
Watch this space for the full review once I’ve put the 12-week claims to the test myself.
