If you have recently become interested in cosmetic surgery or aesthetic treatments to help bring your best version to light, then you have probably heard of Harley Street.
Not? It is world-famous for its concentration of private medical specialists and clinics, set in the heart of London. Today, there are around 2,000 well-known medical practitioners in and around, plus over 250 clinics in the Harley Street area. One of these prestigious clinics is 111 Harley St. And it is a clinic like no other.
Founded by Dr Yannis Alexandrides, a triple-board-certified plastic surgeon, in 2001, Dr Alexandrides has performed over 12,000 surgeries at 111 Harley St. alone. Not to mention, the clinic as a whole performs 10,000+ invasive and non-invasive treatments annually, with patients coming from over 89 countries each year.

That is pretty astounding. A true testament to the trust (and reputation) placed in this practice
Being triple board-certificed aside, Dr Alexandrides is a renowned plastic and reconstructive surgeon whose expertise has transcended the operating room to revolutionise the skincare industry. He is not only the founder and medical director of 111 Harley St., but the founder of 111SKIN too.
Born in Athens, Greece, he began his medical studies there before moving to the United States to specialise in plastic and reconstructive surgery, graduating from the University of Miami. In addition, as a founding faculty member of the prestigious NYC Facelift Master Course, Dr Yannis Alexandrides shares his expertise with surgeons worldwide, helping to shape the future of aesthetic surgery.
With multiple award nominations to his name, Dr Yannis is, without a doubt, the go-to person for those seeking exceptional results.
Let’s Talk About 111 Harley St.
111 Harley St. is celebrated for pushing the boundaries of both surgical aesthetics and skincare. This multi-award-winning clinic offers a wide range of surgical and non-surgical procedures, including Dr Yannis Alexandrides’ signature Y-Facelift.
The clinic also follows a comprehensive, 360-degree philosophy, designed to help each patient achieve their personal aesthetic goals in the least invasive (and most successful and effective) way possible. For almost two decades, 111 Harley St. has remained at the forefront of aesthetic innovation due to Dr Yannis’s tireless approach to medical excellence.
Of course, the clinic also boasts a highly experienced team that combines advanced techniques, the latest technology, and clinically proven products. It also goes without saying that every patient journey is entirely bespoke. For surgical patients, the clinic offers comprehensive follow-up care for a full year after the procedure, ensuring optimal recovery and truly outstanding results.
Patients travel not only from across London and the UK, but from all around the world, to experience the clinic’s meticulous approach and unrivaled standard of excellence.

The Birth Of 111SKIN
In 2012, Dr Yannis launched 111SKIN, marking a major milestone in his career. His goal was to create skincare products that would support and enhance the results of cosmetic surgery. Drawing on his clinical experience, he developed formulas designed to help skin recover and strengthen after procedures.
A turning point came when Dr Alexandrides collaborated with scientists from the European Space Agency. Together, they created the brand’s signature NAC Y2™ complex, originally developed to protect astronauts’ skin from the effects of cosmic radiation. This breakthrough ingredient remains at the heart of 111SKIN’s range and reflects Dr Alexandrides’ commitment to combining advanced science with skincare innovation.
Since its launch, 111SKIN has grown into a global luxury skincare brand, offering over 60 products across six specialised ranges. In 2023, the company reported £20.3 million in revenue, with the majority of sales coming from international markets. Clinical studies of the NAC Y2™ complex have shown impressive results, in a trial of 113 participants over 84 days, 92% reported healthier-looking skin, 95% said their skin felt more hydrated, and 88% noticed a more even skin tone.
Naturally, Dr Alexandrides’ approach to skincare is rooted in his surgical background. He emphasises the importance of understanding the skin’s needs and developing products that deliver clinical-strength results. His formulations aim to replicate the benefits of in-clinic treatments, offering consumers effective alternatives for skin rejuvenation and healing.
What Patients Are Saying
From getting an eye lift to a chin implant, breast reduction to mesotherapy, 111 Harley St. offers it all, with meticulous attention to detail, precision, and safety.
The clinic has also been featured in publications like British Vogue, The Guardian, BBC, GQ, Fobres, the Financial Times, and more!

But here is what former patients have to say about their experience:
“Jamy is absolutely amazing. She is very thorough, gentle with treatment, knowledgeable and experienced. I would give her 6 stars if I can (5 stars is not enough!!)” -CH
“My experience with Dr Yannis Alexandrides and his staff was exceptional. From the moment you walk into 111 Harley St., you are made to feel truly welcome. The consultation with Dr. Yannis was on another level, reassuring, informative, and conducted with genuine care. He took the time to explain everything in depth, making me feel confident that the procedure I was considering was the right choice. I left feeling fully informed and in very capable hands.” – DG
“Good consultation that answered all the important questions for anyone new to these type treatments. Nice and knowledgeable staff, great treatment with healing times as explained. And, even for a skeptic like myself, you can definitely see the results!” – JM
The Last Word On Excellence
Dr Yannis Alexandrides has built more than just a clinic, he has created one of the world’s leading destinations for cosmetic surgery and skincare, giving patients results that truly make a difference.
With a commitment to innovation, education, and high-quality care, 111 Harley St. continues to set the standard for aesthetic medicine, to help every patient achieve their personal vision of beauty.









