There’s a new name making waves in the world of aesthetic treatments – and if you’re someone who prefers subtle, natural-looking results over the “frozen” look, this one’s for you.
Polynucleotides – once a clinical-sounding term confined to medical journals – are quickly becoming one of the most sought-after injectable treatments in UK clinics. In fact, online searches for the word have skyrocketed, with over 55,000 Google searches in the past month alone. That’s a 133% increase year-on-year, according to the beauty experts at Fresha, the world’s top-rated beauty and wellness booking platform.
But what exactly are polynucleotides, and why are aesthetic clients ditching Botox in favour of this cutting-edge injectable?
What Are Polynucleotides?
Polynucleotides (often abbreviated to PN) are injectable treatments made from highly purified fragments of DNA – typically derived from fish, but don’t worry, it’s processed to be safe and well tolerated.
Unlike Botox, which works by relaxing facial muscles to reduce movement (and thus wrinkles), polynucleotides focus on skin regeneration from within. They stimulate your body’s natural fibroblasts – the cells responsible for producing collagen and elastin, the key building blocks of youthful, healthy skin.
The result? Firmer, plumper, more hydrated skin – without adding volume or freezing movement. This makes polynucleotides ideal for clients looking for natural rejuvenation rather than dramatic changes.
Why Are Polynucleotides Trending?
According to specialists using the Fresha platform, more and more clients are asking for polynucleotides by name. The treatment is especially popular with those who are already familiar with aesthetics and are seeking long-term skin health, rather than a quick fix.
Here are just a few reasons why it’s catching on:
- Skin regeneration – smoother, firmer texture and tone
- Hydration boost – improved elasticity and moisture retention
- Calming effect – helps reduce redness and inflammation
- Delicate areas – perfect for the under-eyes, neck, and décolleté
- Versatile – pairs beautifully with microneedling, PRP, and even fillers
One aesthetician on Fresha put it simply:
“Polynucleotides are changing the game. Clients no longer want dramatic changes – they want natural improvements in skin quality. We’re seeing more requests than ever, especially as awareness grows on TikTok and in the press.”
The Future of Injectables?
Botox and fillers have been aesthetic staples for decades – and they’re not going anywhere. But a new generation of clients is now looking for treatments that do more than mask ageing. They want treatments that regenerate and restore.
Polynucleotides offer just that – a regenerative approach to skincare that improves the skin’s condition over time, rather than delivering instant (and sometimes obvious) changes.
As one practitioner put it:
“Botox and fillers will always have their place, but polynucleotides are part of a bigger movement towards regenerative aesthetics. For many clients, it feels like the future of injectables.”
Are There Any Side Effects?
As with all injectable treatments, some side effects are possible – including redness, swelling, or bruising at the injection site. Most treatment plans involve 2–3 sessions, spaced a few weeks apart, with results building gradually.
It’s also worth noting that polynucleotide treatments aren’t suitable for those who are pregnant, breastfeeding, or have fish allergies (as the DNA fragments are usually derived from fish).
Thinking About Trying Polynucleotides?
Whether you’re new to injectables or already a seasoned pro, polynucleotides could be a great option if you’re looking for natural, regenerative results without altering your facial expressions or adding volume.
At Parlor Beauty, we’re always staying ahead of the curve with the latest innovations in aesthetic skincare. If you’re curious about polynucleotides or want to find out if they’re right for you, don’t hesitate to reach out to our expert team – we’re here to help you look and feel your best.
R
